Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives
A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …
compound with wide ranges of pharmacological activities due to different mechanisms of …
Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR)
A Kumari, RK Singh - Bioorganic Chemistry, 2020 - Elsevier
Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding
heterocyclic motif with wide ranges of pharmacological activities due to different …
heterocyclic motif with wide ranges of pharmacological activities due to different …
Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological …
Fragment merging approach was applied for the design of thiazole/thiazolidinone clubbed
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …
A review of the therapeutic importance of indole scaffold in drug discovery
Indole is known as a versatile heterocyclic building block for its multiple pharmacological
activities and has a high probability of success in the race for drug candidates. Many natural …
activities and has a high probability of success in the race for drug candidates. Many natural …
Synthesis, structure characterization, in vitro and in silico biological evaluation of a new series of thiazole nucleus integrated with pyrazoline scaffolds
In the current study, a series of 2, 4-disubstituted-1, 3-thiazoles linked with pyrazoline
scaffolds 3a-o were rationally designed and synthesized. The structures of the title …
scaffolds 3a-o were rationally designed and synthesized. The structures of the title …
[PDF][PDF] Synthesis of new thiazole and thiazolyl derivatives of medicinal significant-a short review
W Hussein, G Turan - MOJ Biorg. Org. Chem, 2018 - researchgate.net
In the field of therapeutic science, thiazoles are of extraordinary importance, because of their
potent and significant biological activities. Likewise thiazole and their derivatives are found …
potent and significant biological activities. Likewise thiazole and their derivatives are found …
Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives
ABSTRACT A series of novel 2-(4-(aryl) thiazol-2-yl)-3a, 4, 7, 7a-tetrahydro-1 H-4, 7-
ethanoisoindole-1, 3 (2 H)-dione derivatives were synthesized and evaluated for their …
ethanoisoindole-1, 3 (2 H)-dione derivatives were synthesized and evaluated for their …
Indole and indoline scaffolds in drug discovery
F Liu, M Su - Privileged Scaffolds in Drug Discovery, 2023 - Elsevier
As privileged scaffolds and versatile pharmacophores, indole and indoline demonstrate an
array of biological activities relevant to numerous human diseases and are present in many …
array of biological activities relevant to numerous human diseases and are present in many …
Design and synthesis of new 1, 3, 4-oxadiazole–benzothiazole and hydrazone derivatives as promising chemotherapeutic agents
Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series
of hydrazide and oxadiazole derivatives were designed and synthesized using 3 …
of hydrazide and oxadiazole derivatives were designed and synthesized using 3 …
Recent advancements on biological activity of indole and their derivatives: A review
Indole, a versatile outstanding heterocyclic compound, engaged in numerous
pharmacological properties due to their multiple biochemical processes. The remarkable …
pharmacological properties due to their multiple biochemical processes. The remarkable …