Transcription factor clusters enable target search but do not contribute to target gene activation
JVW Meeussen, W Pomp, I Brouwer… - Nucleic Acids …, 2023 - academic.oup.com
Many transcription factors (TFs) localize in nuclear clusters of locally increased
concentrations, but how TF clustering is regulated and how it influences gene expression is …
concentrations, but how TF clustering is regulated and how it influences gene expression is …
Why Does the Antioxidant Complex Twendee X® Prevent Dementia?
F You, Y Harakawa, T Yoshikawa… - International Journal of …, 2023 - mdpi.com
Abstracts Alzheimer's disease (AD) is a complex neurodegenerative disease characterized
by cognitive and short-term memory impairments. The disease involves multiple …
by cognitive and short-term memory impairments. The disease involves multiple …
[HTML][HTML] Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase
S Yokomizo, M Roessing, A Morita, T Kopp… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
There is solid evidence of the beneficial effect of photobiomodulation (PBM) with low-power
near-infrared (NIR) light in the NIR-I window in increasing bioavailable nitric oxide (NO) …
near-infrared (NIR) light in the NIR-I window in increasing bioavailable nitric oxide (NO) …
Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p. D620N knock-in mice
Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and
learning behaviors, and can be observed during the prodromal phase of Parkinson's …
learning behaviors, and can be observed during the prodromal phase of Parkinson's …
An effector of 'Candidatus Liberibacter asiaticus' manipulates autophagy to promote bacterial infection
H Shi, Z Yang, J Huang, H Wu, S Fu, W Li… - Journal of …, 2023 - academic.oup.com
Autophagy functions in plant host immunity responses to pathogen infection. The molecular
mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular …
mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular …
Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae
S Schrott, C Osman - Nucleic Acids Research, 2023 - academic.oup.com
The mitochondrial genome, mtDNA, is present in multiple copies in cells and encodes
essential subunits of oxidative phosphorylation complexes. mtDNA levels have to change in …
essential subunits of oxidative phosphorylation complexes. mtDNA levels have to change in …
Differential role of aldosterone and transforming growth factor beta-1 in cardiac remodeling
P Kmieć, S Rosenkranz, M Odenthal… - International Journal of …, 2023 - mdpi.com
Angiotensin II, a major culprit in cardiovascular disease, activates mediators that are also
involved in pathological cardiac remodeling. In this context, we aimed at investigating the …
involved in pathological cardiac remodeling. In this context, we aimed at investigating the …
Lipopolysaccharide transport regulates bacterial sensitivity to a cell wall-degrading intermicrobial toxin
KL Trotta, BM Hayes, JP Schneider, J Wang… - PLoS …, 2023 - journals.plos.org
Gram-negative bacteria can antagonize neighboring microbes using a type VI secretion
system (T6SS) to deliver toxins that target different essential cellular features. Despite the …
system (T6SS) to deliver toxins that target different essential cellular features. Despite the …
The neuronal transcription factor MEIS2 is a calpain-2 protease target
T Müller, M Reichlmeir, AC Hau, I Wittig… - Journal of Cell …, 2024 - journals.biologists.com
Tight control over transcription factor activity is necessary for a sensible balance between
cellular proliferation and differentiation in the embryo and during tissue homeostasis by …
cellular proliferation and differentiation in the embryo and during tissue homeostasis by …
RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses
Background Parkinson's disease is a progressive neurodegenerative disorder with
multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are …
multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are …