Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with
increasing age, being a major component in the development of frailty. Current knowledge …

Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Caveolae are invaginations of the plasma membrane involved in many cellular processes,
including clathrin-independent endocytosis, cholesterol transport, and signal transduction …

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …

Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a
devastating complication of cancer associated with poor quality of life and increased …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …