The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for
the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be
isolated from cells suggest that biological membranes are not always in a liquid-crystalline …

Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important
regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but …

Vasodilator actions of insulin are mediated by activation of endothelial nitric-oxide synthase
(eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play …

Rather than being a constitutive enzyme as was first suggested, endothelial nitric oxide
synthase (eNOS) is dynamically regulated at the transcriptional, posttranscriptional, and …