Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

Abstract Thyroid hormones (TH) 3, 5, 3′, 5'-tetraiodothyronine or thyroxine (T4) and 3, 5, 3'-
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …

Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

The trace element selenium is an essential micronutrient that is required for the biosynthesis
of selenocysteine-containing selenoproteins. Most of the known selenoproteins are …

Abstract In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid
was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and …

The sodium/iodide symporter mediates active iodide transport in both healthy and
cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades …

The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …

Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake
occurs across the membrane of the thyroid follicular cells through an active transporter …