Over the last decade, many catalytically active DNA molecules (deoxyribozymes; DNA
enzymes) have been identified by in vitro selection from random-sequence DNA pools. This …

Electroporation has been used extensively to transfer DNA to bacteria, yeast, and
mammalian cells in culture for the past 30 years. Over this time, numerous advances have …

Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation
(also denoted electrogene transfer or electrokinetic enhancement). This approach is safe …

The past decade has seen the rapid evolution of small-molecule gene-silencing strategies,
driven largely by enhanced understanding of gene function in the pathogenesis of disease …

The study of muscle physiology has undergone many changes over the past 25 years and
has moved from purely physiological studies to those intimately intertwined with molecular …

The latent membrane protein (LMP1) encoded by Epstein–Barr virus (EBV) has been
suggested to be one of the major oncogenic factors in EBV-mediated carcinogenesis. RNA …

Gene therapy may represent a promising alternative strategy for cardiac muscle
regeneration. In vivo electroporation, a physical method of gene transfer, has recently …

Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to
have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC) …

Echogenic liposomes (ELIP) have additional promise, beyond diagnostic agents, as
vehicles for delivering oligonucleotides (ODN), especially if the release of the agent can be …

Deoxyribozymes (DNAzymes) comprise an exciting class of nucleic acid molecules that are
capable of specific cleavage of target mRNA. Recent reports attest to the potential of this …