Cancer-associated cachexia—understanding the tumour macroenvironment and microenvironment to improve management

JM Argilés, FJ López-Soriano, B Stemmler… - Nature Reviews …, 2023 - nature.com
Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Update on the treatment of cancer cachexia

K Nishie, T Nishie, S Sato, M Hanaoka - Drug Discovery Today, 2023 - Elsevier
Cancer cachexia is a complex multifaceted syndrome involving functional impairment and
changes in body composition that cannot be reversed by nutritional support. Cancer …

Synthetic approaches to the new drugs approved during 2021

EL McInturff, SP France, CA Leverett… - Journal of Medicinal …, 2023 - ACS Publications
Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Involvement of the gut microbiota in cancer cachexia

BN VanderVeen, TD Cardaci… - … of Physiology-Cell …, 2024 - journals.physiology.org
Cancer cachexia, or the unintentional loss of body weight in patients with cancer, is a
multiorgan and multifactorial syndrome with a complex and largely unknown etiology; …

The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind …

Y Khazaei, A Basi, ML Fernandez, H Foudazi… - … Medicine and Therapies, 2023 - Springer
Background The prevalence of breast cancer and its mortality rate are increasing rapidly
among women worldwide. On other hand, the courses of chemotherapy as the main …

The contribution of tumor derived exosomes to cancer cachexia

CR Pitzer, HG Paez, SE Alway - Cells, 2023 - mdpi.com
Cancer cachexia is defined as unintentional weight loss secondary to neoplasia and is
associated with poor prognosis and outcomes. Cancer cachexia associated weight loss …

Exploring heterogeneity: A dive into preclinical models of cancer cachexia

F Morena, AR Cabrera… - American Journal of …, 2024 - journals.physiology.org
Cancer cachexia (CC) is a multifactorial and complex syndrome experienced by up to 80%
of patients with cancer and implicated in∼ 40% of cancer-related deaths. Given its …

Mirtazapine versus megestrol in the treatment of anorexia–cachexia syndrome in patients with advanced cancer: a randomized, double-blind, controlled phase II …

OLS Almeida, E Ferriolli, RCC Taveira, MG Rosenburg… - Cancers, 2023 - mdpi.com
Simple Summary This study compared mirtazapine with megestrol in the management of
cancer-related anorexia–cachexia syndrome in patients with advanced cancer. This is a …

Mechanisms of Ovarian Cancer-Associated Cachexia

CS Callaway, LM Mouchantat, BG Bitler… - Endocrinology, 2024 - academic.oup.com
Cancer-associated cachexia occurs in 50% to 80% of cancer patients and is responsible for
20% to 30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and …

[HTML][HTML] An Assessment of Behavioral Risk Factors in Oncology Patients

M Mititelu, M Licu, SM Neacșu, MF Călin, SR Matei… - Nutrients, 2024 - mdpi.com
An evaluation of the behavioral risk factors that contribute to the incidence and evolution of
cancer in oncology patients was conducted through a cross-sectional study using a …