The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Vertebral bone is subject to a distinct set of disease processes from long bones, including a
much higher rate of solid tumour metastases,,–. The basis for this distinct biology of vertebral …

Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

The major mineralized tissues are bone and teeth, which share several mechanisms
governing their development and mineralization. This crossover includes the hormones that …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Dental follicle cells (DFCs) are a group of mesenchymal progenitor cells surrounding the
tooth germ, responsible for cementum, periodontal ligament, and alveolar bone formation in …

A comprehensive understanding of the extracellular matrix (ECM) is essential for developing
biomimetic ECM scaffolds for tissue regeneration. As the periodontal ligament cell (PDLC) …