Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Abstract Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse
cellular processes, including tumorigenesis, and its overexpression is observed in cell lines …

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …

Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour
suppressors involved in carcinogenesis. Here we characterized an oncogenic long …

Arginine methylation is a common posttranslational modification (PTM). This type of PTM
occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling …