Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Advances in nanomaterial-based targeted drug delivery systems
X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics
Y Di, R Deng, Z Liu, Y Mao, Y Gao, Q Zhao, S Wang - Biomaterials, 2023 - Elsevier
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor
growth, metastasis, death and other biological processes. ROS-based nanodynamic …
growth, metastasis, death and other biological processes. ROS-based nanodynamic …
Recent advances in dual-and multi-responsive nanomedicines for precision cancer therapy
Nanomedicines have been regarded as a potential approach in the field of cancer treatment
due to their unique advantages. Although improved therapeutic efficacy can be achieved …
due to their unique advantages. Although improved therapeutic efficacy can be achieved …
Current limitations and recent progress in nanomedicine for clinically available photodynamic therapy
Photodynamic therapy (PDT) using oxygen, light, and photosensitizers has been receiving
great attention, because it has potential for making up for the weakness of the existing …
great attention, because it has potential for making up for the weakness of the existing …
Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy
Z Cao, D Li, J Wang, X Yang - Acta Biomaterialia, 2021 - Elsevier
Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest
in recent years. On the one hand, a high ROS level has been detected in many types of …
in recent years. On the one hand, a high ROS level has been detected in many types of …
Reactive oxygen species activatable heterodimeric prodrug as tumor-selective nanotheranostics
Nanotheranostics based on tumor-selective small molecular prodrugs could be more
advantageous in clinical translation for cancer treatment, given its defined chemical …
advantageous in clinical translation for cancer treatment, given its defined chemical …
pH/ROS dual-responsive supramolecular polypeptide prodrug nanomedicine based on host-guest recognition for cancer therapy
Y Ding, C Wang, Y Ma, L Zhu, B Lu, Y Wang, J Wang… - Acta Biomaterialia, 2022 - Elsevier
Supramolecular nanomedicine assembly combined with polypeptide prodrug could become
a powerful strategy to minimize drug leakage in blood circulation and trigger sufficient drug …
a powerful strategy to minimize drug leakage in blood circulation and trigger sufficient drug …
Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy
Photodynamic therapy (PDT), in which a light source is used in combination with a
photosensitizer to induce local cell death, has shown great promise in therapeutically …
photosensitizer to induce local cell death, has shown great promise in therapeutically …
Supramolecular theranostic nanomedicine for in situ self-boosting cancer photochemotherapy
D Wu, Z Zhang, X Li, T Zhu, J Wang, Q Hu - Biomacromolecules, 2023 - ACS Publications
Although traditional nanomedicines have enhanced the therapeutic efficacy and improved
the survival quality of cancer patients, random drug release and drug resistance are deep …
the survival quality of cancer patients, random drug release and drug resistance are deep …