Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Y Di, R Deng, Z Liu, Y Mao, Y Gao, Q Zhao, S Wang - Biomaterials, 2023 - Elsevier
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor
growth, metastasis, death and other biological processes. ROS-based nanodynamic …

Recent advances in dual-and multi-responsive nanomedicines for precision cancer therapy

Y Zhang, J Li, K Pu - Biomaterials, 2022 - Elsevier
Nanomedicines have been regarded as a potential approach in the field of cancer treatment
due to their unique advantages. Although improved therapeutic efficacy can be achieved …

Current limitations and recent progress in nanomedicine for clinically available photodynamic therapy

J Park, YK Lee, IK Park, SR Hwang - Biomedicines, 2021 - mdpi.com
Photodynamic therapy (PDT) using oxygen, light, and photosensitizers has been receiving
great attention, because it has potential for making up for the weakness of the existing …

Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy

Z Cao, D Li, J Wang, X Yang - Acta Biomaterialia, 2021 - Elsevier
Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest
in recent years. On the one hand, a high ROS level has been detected in many types of …

Reactive oxygen species activatable heterodimeric prodrug as tumor-selective nanotheranostics

M Jiang, J Mu, O Jacobson, Z Wang, L He, F Zhang… - ACS …, 2020 - ACS Publications
Nanotheranostics based on tumor-selective small molecular prodrugs could be more
advantageous in clinical translation for cancer treatment, given its defined chemical …

pH/ROS dual-responsive supramolecular polypeptide prodrug nanomedicine based on host-guest recognition for cancer therapy

Y Ding, C Wang, Y Ma, L Zhu, B Lu, Y Wang, J Wang… - Acta Biomaterialia, 2022 - Elsevier
Supramolecular nanomedicine assembly combined with polypeptide prodrug could become
a powerful strategy to minimize drug leakage in blood circulation and trigger sufficient drug …

Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy

Y Hao, CK Chung, Z Yu, RV Huis in 't Veld… - Pharmaceutics, 2022 - mdpi.com
Photodynamic therapy (PDT), in which a light source is used in combination with a
photosensitizer to induce local cell death, has shown great promise in therapeutically …

Supramolecular theranostic nanomedicine for in situ self-boosting cancer photochemotherapy

D Wu, Z Zhang, X Li, T Zhu, J Wang, Q Hu - Biomacromolecules, 2023 - ACS Publications
Although traditional nanomedicines have enhanced the therapeutic efficacy and improved
the survival quality of cancer patients, random drug release and drug resistance are deep …