Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune
response to destroy host and viral RNA to ultimately reduce viral gene expression. Herein …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Stress-induced readthrough transcription results in the synthesis of downstream-of-gene
(DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular …

Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and
host proteins required for viral replication are typically spared in this process, but the …

The current model is that the influenza virus polymerase (FluPol) binds either to host RNA
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …

Early interactions of influenza A virus (IAV) with respiratory epithelium might determine the
outcome of infection. The study of global cellular innate immune responses often masks …

Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus associated with multiple cancers
and autoimmune diseases. Unlike most herpesviruses, EBV reactivation from latency occurs …

Many viruses block host gene expression to take over the infected cell. This process, termed
host shutoff, is thought to promote viral replication by preventing antiviral responses and …