Metformin and malignant tumors: not over the hill

W Leng, J Jiang, B Chen, Q Wu - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Malignant tumors are a major cause of death, and their incidence is increasing worldwide.
Although the survival rate for some cancers has improved, treatments for other malignant …

Ferroptosis: Frenemy of Radiotherapy

L Kerkhove, F Geirnaert, I Dufait… - International Journal of …, 2024 - mdpi.com
Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death,
plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers …

[HTML][HTML] Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy

JA Nickoloff, L Taylor, N Sharma… - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
More than half of cancer patients are treated with radiotherapy, which kills tumor cells by
directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks …

In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K …

RA Almaimani, A Aslam, J Ahmad, MZ El-Readi… - Cancers, 2022 - mdpi.com
Simple Summary Failure of chemotherapy is common during the treatment of colon cancer,
and there is a compelling need to develop alternative therapeutic approaches against this …

Machine learning based prediction of recurrence after curative resection for rectal cancer

Y Jeon, YJ Kim, J Jeon, KH Nam, TS Hwang, KG Kim… - Plos one, 2023 - journals.plos.org
Purpose Patients with rectal cancer without distant metastases are typically treated with
radical surgery. Post curative resection, several factors can affect tumor recurrence. This …

Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

M Tojo, H Miyato, K Koinuma, H Horie, H Tsukui… - Scientific reports, 2022 - nature.com
Although preoperative chemoradiation therapy can down-stage locally advanced rectal
cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer …

[HTML][HTML] Метформин и злокачественные новообразования: возможный механизм противоопухолевого действия и перспективы использования в практике

КО Кузнецов, ЭР Сафина, ДВ Гаймакова… - Проблемы …, 2022 - cyberleninka.ru
Метформин является противодиабетическим препаратом первой линии для лечения
сахарного диабета 2 типа (СД2); его молекулярной мишенью является АМФ …

[HTML][HTML] Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes

QY Huang, F Yao, CR Zhou, XY Huang… - World journal of …, 2020 - ncbi.nlm.nih.gov
The prevalence of colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) is
increasing globally. It is rarely noticed that the incidence of CRC is higher in patients with …

Self-assembled mesoporous particles of Antheraea pernyi silk fibroin for encapsulation and sustained release of 5-fluorouracil

S Du, Y Wei, Y Tan, Y Li, J Li, T Wu, L Han… - Colloids and Surfaces A …, 2023 - Elsevier
Mesoporous particles have attracted considerable attention in drug delivery system,
because they can offer fast mass transport and overcome the diffusion restriction as …

Body mass index–based predictions and personalized clinical strategies for colorectal cancer in the context of PPPM

YJ Gu, LM Chen, ME Gu, HX Xu, J Li, LY Wu - EPMA Journal, 2022 - Springer
Currently colorectal cancer (CRC) is the third most prevalent cancer worldwide. Body mass
index (BMI) is frequently used in CRC screening and risk assessment to quantitatively …