The mur enzymes chink in the armour of Mycobacterium tuberculosis cell wall
Tuberculosis (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment
The present-day world is severely suffering from the recently emerged SARS-CoV-2. The
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …
Targeting polyketide synthase 13 for the treatment of tuberculosis
F Xia, H Zhang, H Yang, M Zheng, W Min, C Sun… - European Journal of …, 2023 - Elsevier
Tuberculosis (TB) is one of the most threatening diseases for humans, however, the drug
treatment strategy for TB has been stagnant and inadequate, which could not meet current …
treatment strategy for TB has been stagnant and inadequate, which could not meet current …
Identification of Novel SARS‐CoV‐2 Inhibitors: A Structure‐Based Virtual Screening Approach
A El Aissouq, O Chedadi, M Bouachrine… - Journal of …, 2021 - Wiley Online Library
The recent outbreak of the coronavirus disease 2019 (COVID‐19) caused by SARS‐CoV‐2
(severe acute respiratory syndrome coronavirus 2) in the last few months raised global …
(severe acute respiratory syndrome coronavirus 2) in the last few months raised global …
Rational designing of peptide-ligand conjugates-based immunotherapy for the treatment of complicated malaria
Aims Malaria deaths occur primarily due to complicated malaria associated with the
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …
Discovery of potential antiviral compounds against hendra virus by targeting its receptor-binding protein (G) using computational approaches
Hendra virus (HeV) belongs to the paramyxoviridae family of viruses which is associated
with the respiratory distress, neurological illness, and potential fatality of the affected …
with the respiratory distress, neurological illness, and potential fatality of the affected …
Structure-based virtual screening approach reveals natural multi-target compounds for the development of antimalarial drugs to combat drug resistance
Compared to the previous year, there has been an increase of nearly 2 million malaria
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …
Identification of potent human carbonic anhydrase IX inhibitors: a combination of pharmacophore modeling, 3D-QSAR, virtual screening and molecular dynamics …
Human carbonic anhydrase IX (hCA IX) is a promising target for the development of
potential anticancer agents. In the current study, pharmacophore and 3D-QSAR models …
potential anticancer agents. In the current study, pharmacophore and 3D-QSAR models …
In silico screening of dicoumarols as potential Mur B enzyme inhibitors in Mycobacterium tuberculosis: molecular docking, ADME, QSAR and MD simulations
UDP-N-acetylenolpyruvoylglucosamine reductase (Mur B) from Mycobacterium tuberculosis
has gathered significant pharmaceutical interest as a pivotal target because of its essential …
has gathered significant pharmaceutical interest as a pivotal target because of its essential …
Molecular docking based comparative study of antiviral compounds on SARS-CoV-2 spike protein
The urgent need for effective therapeutic interventions against SARS-CoV-2 has prompted
extensive exploration of potential drug candidates. Among the viral proteins, the spike (S) …
extensive exploration of potential drug candidates. Among the viral proteins, the spike (S) …