Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in
mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

BACKGROUND The LH surge induces great physiological changes within the preovulatory
follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Ovulation is stimulated by the preovulatory surge of the pituitary luteinizing hormone (LH).
Because the ovulatory response is commonly identified with inflammation, we explored the …

During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the
somatic and germ cell compartments of the ovarian follicle. The oocyte completes the …