The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Recent advances in understanding the protein corona of nanoparticles and in the formulation of “stealthy” nanomaterials

R Rampado, S Crotti, P Caliceti, S Pucciarelli… - … in bioengineering and …, 2020 - frontiersin.org
In the last decades, the staggering progress in nanotechnology brought around a wide and
heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of …

Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Cloaking nanoparticles with protein corona shield for targeted drug delivery

JY Oh, HS Kim, L Palanikumar, EM Go, B Jana… - Nature …, 2018 - nature.com
Targeted drug delivery using nanoparticles can minimize the side effects of conventional
pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based …

Interplay of protein corona and immune cells controls blood residency of liposomes

F Giulimondi, L Digiacomo, D Pozzi, S Palchetti… - Nature …, 2019 - nature.com
In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological
identity'due to the formation of a biomolecular coating known as the protein corona that …

Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

S Xu, H Zheng, R Ma, D Wu, Y Pan, C Yin… - Nature …, 2020 - nature.com
Sustainable developments of nanotechnology necessitate the exploration of structure-
activity relationships (SARs) at nano-bio interfaces. While ferroptosis may contribute in the …

Emerging understanding of the protein corona at the nano-bio interfaces

M Mahmoudi, N Bertrand, H Zope, OC Farokhzad - Nano Today, 2016 - Elsevier
Upon entering the physiological environment, nanoparticles (NPs) are immediately
surrounded by a complex and tightly bound layer of biomolecules, or '(hard) protein corona' …

Protein nanoparticle charge and hydrophobicity govern protein corona and macrophage uptake

SM Pustulka, K Ling, SL Pish… - ACS Applied Materials & …, 2020 - ACS Publications
Protein nanoparticles are biomaterials composed entirely of proteins, with the protein
sequence and structure determining the nanoparticle physicochemical properties. Upon …

Biocompatibility of nanomaterials and their immunological properties

TR Kyriakides, A Raj, TH Tseng, H Xiao… - Biomedical …, 2021 - iopscience.iop.org
Nanomaterials (NMs) have revolutionized multiple aspects of medicine by enabling novel
sensing, diagnostic, and therapeutic approaches. Advancements in processing and …

Protein bio-corona: critical issue in immune nanotoxicology

M Neagu, Z Piperigkou, K Karamanou, AB Engin… - Archives of …, 2017 - Springer
With the expansion of the nanomedicine field, the knowledge focusing on the behavior of
nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex …