Unconventional protein secretion–new insights into the pathogenesis and therapeutic targets of human diseases
Most secretory proteins travel through a well-documented conventional secretion pathway
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …
Unconventional secretion of heat shock proteins in cancer
Heat shock proteins (HSPs) are abundant cellular proteins involved with protein
homeostasis. They have both constitutive and inducible isoforms, whose expression levels …
homeostasis. They have both constitutive and inducible isoforms, whose expression levels …
The role of heat shock proteins in type 1 diabetes
ASM Moin, M Nandakumar, A Diane, M Dehbi… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by
recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs) …
recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs) …
Does Hsp60 provide a link between mitochondrial stress and inflammation in diabetes mellitus?
J Juwono, RD Martinus - Journal of Diabetes Research, 2016 - Wiley Online Library
The focus of this review is to summarise the known relationships between the expression of
heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type …
heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type …
Anti-CD3/anti-CXCL10 antibody combination therapy induces a persistent remission of type 1 diabetes in two mouse models
S Lasch, P Müller, M Bayer, JM Pfeilschifter… - Diabetes, 2015 - Am Diabetes Assoc
Anti-CD3 therapy of type 1 diabetes results in a temporary halt of its pathogenesis but does
not constitute a permanent cure. One problem is the reinfiltration of islets of Langerhans with …
not constitute a permanent cure. One problem is the reinfiltration of islets of Langerhans with …
[HTML][HTML] Comparison of T helper cell patterns in primary open-angle glaucoma and normal-pressure glaucoma
Background HSP60-related immunological activities are found in normal-pressure
glaucoma (NPG) patients, in whom an elevated intraocular pressure (IOP) found in primary …
glaucoma (NPG) patients, in whom an elevated intraocular pressure (IOP) found in primary …
New DiaP277 analogue shifts DCs to tolerogenic, and modulates NF-Kβ1 to suppress autoreactive T lymphocytes in the type 1 diabetic mice
Therapeutic efficacy of P277 against type 1 diabetes was extensively investigated and
clinically evidenced. Clinical trials Phases I and II concluded promising results, while the …
clinically evidenced. Clinical trials Phases I and II concluded promising results, while the …
Novel mutant P277 peptide VP to ameliorate atherogenic side-effects and to preserve anti-diabetic effects in NOD mice
P277 is a 24 amino-acids peptide, residues 437–460 of human heat shock protein 60
(HSP60). P277 or sequence repeated 6× P277 was previously found showing potency …
(HSP60). P277 or sequence repeated 6× P277 was previously found showing potency …
Immunotherapy in autoimmune diabetes
Autoimmune diabetes is a chronic autoimmune disease caused by the loss or selective
destruction of the insulin-producing cells, called pancreatic beta cells. Damage to beta cells …
destruction of the insulin-producing cells, called pancreatic beta cells. Damage to beta cells …
[PDF][PDF] Boosting Beta-Cell Replacement Therapy For Treatment Of Type 1 Diabetes
C De Block - 2016 - lirias.kuleuven.be
T1D is a chronic autoimmune pathology characterized by selective destruction of the
insulinproducing beta cells in the pancreas [2]. Until today exogenous insulin administration …
insulinproducing beta cells in the pancreas [2]. Until today exogenous insulin administration …