Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their
receptors in the regulation of blood pressure in normal and disease states has been …

Vascular endothelial cells exhibit substantial phenotypic and transcriptional heterogeneity
which is established during early embryogenesis. However, the molecular mechanisms …

Abstract Knowledge on mode-of-action (MOA) is required to understand toxicological effects
of compounds, notably in the context of risk assessment of mixtures. Such information is …

Orofacial clefts (OFC) are among the most common human congenital birth defects.
Previous multiethnic studies have identified dozens of associated loci for both cleft lip with or …

The engineering of a native‐like articular cartilage (AC) is a long‐standing objective that
could serve the clinical needs of millions of patients suffering from osteoarthritis and …

Conotruncal heart defects (CTDs) are closely related to defective outflow tract (OFT)
development, in which cardiac neural crest cells (CNCCs) play an indispensable role …

Introduction Morphologic features of the mandible are influenced by the genes of each
individual. Mandible size is important to orthodontists because the mandible is the …

Injury to articular cartilage is common, often progresses to a degenerative cycle of
dysfunction and inflammation, and can ultimately result in degenerative joint diseases. The …

The mechanisms behind fate specification are of great interest to developmental biologists.
By understanding how organs form and take shape in the developing embryos, we can …