Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications
Airway epithelial cells and immune cells participate in the inflammatory process responsible
for much of the pathology found in the lung of patients with cystic fibrosis (CF). Intense …
for much of the pathology found in the lung of patients with cystic fibrosis (CF). Intense …
Reflux-aspiration in chronic lung disease
AS Lee, JS Lee, Z He, JH Ryu - Annals of the American Thoracic …, 2020 - atsjournals.org
Microaspiration, or silent aspiration, is commonly suspected in patients with refractory
respiratory symptoms, including unexplained chronic cough, asthma, chronic obstructive …
respiratory symptoms, including unexplained chronic cough, asthma, chronic obstructive …
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis
Although destructive airway disease is evident in young children with cystic fibrosis (CF),
little is known about the nature of the early CF lung environment triggering the disease. To …
little is known about the nature of the early CF lung environment triggering the disease. To …
Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease
JO Hayat, S Gabieta-Somnez, E Yazaki, JY Kang… - Gut, 2015 - gut.bmj.com
Objective Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have
moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in …
moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in …
Respiratory disease and the oesophagus: reflux, reflexes and microaspiration
LA Houghton, AS Lee, H Badri, KR DeVault… - Nature reviews …, 2016 - nature.com
Gastro-oesophageal reflux is associated with a wide range of respiratory disorders,
including asthma, isolated chronic cough, idiopathic pulmonary fibrosis, chronic obstructive …
including asthma, isolated chronic cough, idiopathic pulmonary fibrosis, chronic obstructive …
Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis
FC Ringholz, PJ Buchanan, DT Clarke… - European …, 2014 - Eur Respiratory Soc
Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …
Chronic cough: relationship between microaspiration, gastroesophageal reflux, and cough frequency
S Decalmer, R Stovold, LA Houghton, J Pearson… - Chest, 2012 - Elsevier
Background Microaspiration is often considered a potential cause of cough. The aim of this
study was to investigate the relationship between microaspiration, the degree and type of …
study was to investigate the relationship between microaspiration, the degree and type of …
Bile acids in sputum and increased airway inflammation in patients with cystic fibrosis
A Pauwels, A Decraene, K Blondeau, V Mertens… - Chest, 2012 - Elsevier
Background Up to 80% of patients with cystic fibrosis (CF) may have increased
gastroesophageal reflux and aspiration of duodenogastric contents into the lungs. We aimed …
gastroesophageal reflux and aspiration of duodenogastric contents into the lungs. We aimed …
Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility
TL Samuels, N Johnston - … Opinion in Otolaryngology & Head and …, 2020 - journals.lww.com
Progress continues to be made in our understanding of pepsin-mediated damage with
implications for novel therapeutic strategies. Salivary pepsin diagnostics continue to garner …
implications for novel therapeutic strategies. Salivary pepsin diagnostics continue to garner …
Proximal and distal gastro‐oesophageal reflux in chronic obstructive pulmonary disease and bronchiectasis
AL Lee, BM Button, L Denehy, SJ Roberts… - …, 2014 - Wiley Online Library
Background and objective The aims of this observational study were (i) to examine the
prevalence of symptomatic and clinically silent proximal and distal gastro‐oesophageal …
prevalence of symptomatic and clinically silent proximal and distal gastro‐oesophageal …