Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

Aspergillus fumigatus morphology and dynamic host interactions

FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models

M Seif, TK Kakoschke, F Ebel, MM Bellet… - Science Translational …, 2022 - science.org
Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in
immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis …

Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

S LeibundGut-Landmann, O Groß, MJ Robinson… - Nature …, 2007 - nature.com
The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor
CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs) …

The pathobiology of Aspergillus fumigatus

JP Latgé - Trends in microbiology, 2001 - cell.com
Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed
countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis …

Aspergillus Infections in Transplant Recipients

N Singh, DL Paterson - Clinical microbiology reviews, 2005 - Am Soc Microbiol
Aspergillus infections are occurring with an increasing frequency in transplant recipients.
Notable changes in the epidemiologic characteristics of this infection have occurred; these …

[HTML][HTML] Fungal vaccines, mechanism of actions and immunology: A comprehensive review

S Nami, R Mohammadi, M Vakili, K Khezripour… - Biomedicine & …, 2019 - Elsevier
Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

Killing of Aspergillus fumigatus by Alveolar Macrophages Is Mediated by Reactive Oxidant Intermediates

B Philippe, O Ibrahim-Granet, MC Prevost… - Infection and …, 2003 - Am Soc Microbiol
Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar
macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung …