Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7%
of the global population and more than 500 million people worldwide. One research frontier …

Resistin was originally described as an adipocyte-secreted peptide that induced insulin
resistance in rodents. Increasing evidence indicates its important regulatory roles in various …

Leptin originates in adipocytes, including those in bone marrow, and circulates in
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …

Adiponectin is a recently described adipokine that has been recognized as a key regulator
of insulin sensitivity and tissue inflammation. It is produced by adipose tissue (white and …

Osteoblasts are mononucleated cells that are derived from mesenchymal stem cells and that
are responsible for the synthesis and mineralization of bone during initial bone formation …

Body weight impacts on both bone turnover and bone density, and is therefore an important
risk factor for vertebral and hip fractures, ranking in importance alongside that of age. The …

Body weight is a principal determinant of bone density and fracture risk, and adipose tissue
mass is a major contributor to this relationship. In contrast, some recent studies have argued …

The prevalence of obesity has increased substantially over the past decades in most
industrialized countries. Obesity is a systemic disease that predisposes to a variety of co …

Adiponectin has until now been considered to be synthesized and secreted exclusively by
the adipose tissue, and is reported to influence energy homeostasis and insulin sensitivity. It …