A transporter's doom or destiny: SLC6A1 in health and disease, novel molecular targets and emerging therapeutic prospects
N Shah, AS Kasture, FP Fischer, HH Sitte… - Frontiers in Molecular …, 2024 - frontiersin.org
As the first member of the solute carrier 6 (SLC6) protein family, the γ-aminobutyric acid
(GABA) transporter 1 (GAT1, SLC6A1), plays a pivotal role in the uptake of GABA from the …
(GABA) transporter 1 (GAT1, SLC6A1), plays a pivotal role in the uptake of GABA from the …
[HTML][HTML] An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research
X Zheng - Cells, 2024 - mdpi.com
Studies on numerous species have demonstrated strikingly conserved mechanisms that
determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The …
determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The …
The fruit fly Drosophila melanogaster as a screening model for antiseizure medications
FP Fischer, RA Karge, H Koch, A Voigt… - Frontiers in …, 2024 - frontiersin.org
Objective Resistance to antiseizure medications (ASMs) is a major challenge in the
treatment of patients with epilepsy. Despite numerous newly marketed ASMs, the proportion …
treatment of patients with epilepsy. Despite numerous newly marketed ASMs, the proportion …
Direct Inhibition of BK Channels by Cannabidiol, One of the Principal Therapeutic Cannabinoids Derived from Cannabis sativa
Cannabidiol (CBD), one of the main Cannabis sativa bioactive compounds, is utilized in the
treatment of major epileptic syndromes. Its efficacy can be attributed to a multimodal …
treatment of major epileptic syndromes. Its efficacy can be attributed to a multimodal …
Investigation of epilepsy-related genes in a Drosophila model
X Qu, X Lai, M He, J Zhang, B Xiang, C Liu… - Neural Regeneration … - journals.lww.com
Complex genetic architecture is the major cause of heterogeneity in epilepsy, which poses
challenges for accurate diagnosis and precise treatment. A large number of epilepsy …
challenges for accurate diagnosis and precise treatment. A large number of epilepsy …