The corneal wound healing response is typically initiated by injuries to the epithelium and/or
endothelium that may also involve the stroma. However, it can also be triggered by immune …

Purpose: This review highlights the roles of fibrocytes—their origin, markers, regulation and
functions—including contributions to corneal wound healing and fibrosis. Methods …

Basement membranes are layers of extracellular matrix which anchor the epithelium or
endothelium to connective tissues in most organs. Descemet's membrane—which is the …

Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the
corneal stromal response to infections, injuries, and surgeries, and which produce corneal …

Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor
(TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular …

The purpose of this study was to examine the effect of topical and/or oral angiotensin
converting enzyme II inhibitor and TGF-beta signaling blocker losartan on corneal stromal …

Bacterial keratitis continues to be one of the leading causes of corneal blindness in the
developed as well as the developing world, despite swift progress since the dawn of the …

Bacterial infections of the cornea, or bacterial keratitis (BK), are notorious for causing rapidly
fulminant disease and permanent vision loss, even among treated patients. In the last sixty …

The purpose of this study was to investigate the expression and localization of transforming
growth factor (TGF) β1 and TGFβ2 in rabbit corneas that healed with and without stromal …