Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes

AL Mavor, S Thewes, B Hube - Current drug targets, 2005 - ingentaconnect.com
Candida species, in particular C. albicans, represent a major threat to immunocompromised
patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these …

Genetics of Candida albicans, a Diploid Human Fungal Pathogen

SM Noble, AD Johnson - Annu. Rev. Genet., 2007 - annualreviews.org
Candida albicans is a species of fungus that typically resides in the gastrointestinal tracts of
humans and other warm-blooded animals. It is also the most common human fungal …

Candidalysin is a fungal peptide toxin critical for mucosal infection

DL Moyes, D Wilson, JP Richardson, S Mogavero… - Nature, 2016 - nature.com
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial
pathogens which disrupt epithelial barrier function, damage cells and activate or modulate …

The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH

S Vylkova, AJ Carman, HA Danhof, JR Collette, H Zhou… - MBio, 2011 - Am Soc Microbiol
ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida
albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that …

[HTML][HTML] Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process

B Wächtler, F Citiulo, N Jablonowski, S Förster, F Dalle… - PloS one, 2012 - journals.plos.org
Candida albicans frequently causes superficial infections by invading and damaging
epithelial cells, but may also cause systemic infections by penetrating through epithelial …

[HTML][HTML] NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans

AMA Murad, P Leng, M Straffon, J Wishart… - The EMBO …, 2001 - embopress.org
We have characterized CaNrg1 from Candida albicans, the major fungal pathogen in
humans. CaNrg1 contains a zinc finger domain that is conserved in transcriptional …

[HTML][HTML] From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with …

B Wächtler, D Wilson, K Haedicke, F Dalle, B Hube - PloS one, 2011 - journals.plos.org
Candida albicans frequently causes superficial infections by invading and damaging
epithelial cells, but may also cause systemic infections by penetrating through epithelial …

Candida albicans-induced epithelial damage mediates translocation through intestinal barriers

S Allert, TM Förster, CM Svensson, JP Richardson… - MBio, 2018 - Am Soc Microbiol
Life-threatening systemic infections often occur due to the translocation of pathogens across
the gut barrier and into the bloodstream. While the microbial and host mechanisms …

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood

C Fradin, P De Groot, D MacCallum… - Molecular …, 2005 - Wiley Online Library
Survival in blood and escape from blood vessels into tissues are essential steps for the
yeast Candida albicans to cause systemic infections. To elucidate the influence of blood …

[HTML][HTML] Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion

F Citiulo, ID Jacobsen, P Miramón, L Schild… - PLoS …, 2012 - journals.plos.org
The ability of pathogenic microorganisms to assimilate essential nutrients from their hosts is
critical for pathogenesis. Here we report endothelial zinc sequestration by the major human …