Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Randomized controlled trials for preventing cardiovascular disease indicated that statins
had provocative and unexpected benefits for reducing colorectal cancer and melanoma …

Summary p53 is a frequent target for mutation in human tumors, and mutant p53 proteins
can actively contribute to tumorigenesis. We employed a three-dimensional culture model in …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare but well known entity characterized
by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma …

A wealth of basic science data supports the hypothesis that the surgical stress response
increases the likelihood of cancer dissemination and metastasis during and after cancer …

Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, is often
diagnosed at an advanced stage when most potentially curative therapies such as resection …

Statins are cholesterol-lowering drugs with pleiotropic activities including inhibition of
isoprenylation reactions and reduction of signals driving cell proliferation and survival …

Background: Statins are commonly used cholesterol-lowering drugs that have proapoptotic
and antimetastatic activities that could affect cancer risk or progression. Results from …

Although a change in life-style is often the method of first choice for lipid lowering, lipid-
lowering drugs, in general, help to control elevated levels of different forms of lipids in …

Although statins are lipid-lowering drugs that block cholesterol biosynthesis, they exert
immunomodulatory, anti-inflammatory, anti-angiogenic and anti-proliferative functions by …