The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but
assessing their consistency and reproducibility across iPSC lines, and reducing the …

INTRODUCTION Tissue homeostasis requires the coordinated activity of multiple cell types
to initiate and then resolve inflammation. Endoplasmic reticulum (ER) stress is a hallmark of …

In the past decade, the term organoid has moved from obscurity to common use to describe
a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem …

Chronic kidney disease (CKD) is a major public health concern, underscoring a need to
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …