Biophysical experiments and biomolecular simulations: A perfect match?
S Bottaro, K Lindorff-Larsen - Science, 2018 - science.org
A fundamental challenge in biological research is achieving an atomic-level description and
mechanistic understanding of the function of biomolecules. Techniques for biomolecular …
mechanistic understanding of the function of biomolecules. Techniques for biomolecular …
[HTML][HTML] Principles for integrative structural biology studies
Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …
biological systems based on data produced by multiple experimental and theoretical …
Principles of protein structural ensemble determination
Highlights•The principles of protein structural ensemble determination are described.•The
use of experimental data averaged over multiple states is analysed.•Approaches for …
use of experimental data averaged over multiple states is analysed.•Approaches for …
[HTML][HTML] A Bayesian view on cryo-EM structure determination
SHW Scheres - Journal of molecular biology, 2012 - Elsevier
Three-dimensional (3D) structure determination by single-particle analysis of cryo-electron
microscopy (cryo-EM) images requires many parameters to be determined from extremely …
microscopy (cryo-EM) images requires many parameters to be determined from extremely …
Global structure of the intrinsically disordered protein tau emerges from its local structure
The paradigmatic disordered protein tau plays an important role in neuronal function and
neurodegenerative diseases. To disentangle the factors controlling the balance between …
neurodegenerative diseases. To disentangle the factors controlling the balance between …
[HTML][HTML] CombFold: predicting structures of large protein assemblies using a combinatorial assembly algorithm and AlphaFold2
B Shor, D Schneidman-Duhovny - Nature methods, 2024 - nature.com
Deep learning models, such as AlphaFold2 and RosettaFold, enable high-accuracy protein
structure prediction. However, large protein complexes are still challenging to predict due to …
structure prediction. However, large protein complexes are still challenging to predict due to …
[HTML][HTML] Outcome of the first electron microscopy validation task force meeting
R Henderson, A Sali, ML Baker, B Carragher… - Structure, 2012 - cell.com
This Meeting Review describes the proceedings and conclusions from the inaugural
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …
Nuclear overhauser effect
D Neuhaus - eMagRes, 2007 - Wiley Online Library
The nuclear Overhauser effect (NOE) is defined as the change in intensity of one NMR
resonance that occurs when another is saturated. It results from dipole–dipole cross …
resonance that occurs when another is saturated. It results from dipole–dipole cross …
[HTML][HTML] Leveraging crosslinking mass spectrometry in structural and cell biology
A Graziadei, J Rappsilber - Structure, 2022 - cell.com
Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …
insights into protein conformation and protein-protein interactions. Its medium-resolution …
Structure of the human voltage-dependent anion channel
M Bayrhuber, T Meins, M Habeck… - Proceedings of the …, 2008 - National Acad Sciences
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the
most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel …
most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel …