The bacterial cytoplasmic membrane is composed of roughly equal proportions of lipids and
proteins. The main lipid components are phospholipids, which vary in acyl chain length …

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

For simulations of membranes and membrane proteins, the generation of the lipid bilayer is
a critical step in the setup of the system. Membranes comprising multiple components pose …

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

The lipid bilayer is a 3D assembly with a rich variety of physical features that modulate cell
signaling and protein function. Lateral and transverse forces within the membrane are …

Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Recognition of lipids by proteins is important for their targeting and activation in many
signaling pathways, but the mechanisms that regulate such interactions are largely …

Mitochondria are essential components of eukaryotic cells and are involved in a diverse set
of cellular processes that include ATP production, cellular signalling, apoptosis and cell …

Glycerophospholipids are the most abundant membrane lipid constituents in most
eukaryotic cells. As a consequence, phospholipid class and acyl chain homeostasis are …