[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?
H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …
most significant biological events in cancer progression. Cancer cells generally represent a …
ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways
AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
Natural compounds and products from an anti-aging perspective
Aging is a very complex process that is accompanied by a degenerative impairment in many
of the major functions of the human body over time. This inevitable process is influenced by …
of the major functions of the human body over time. This inevitable process is influenced by …
Selenium, iodine and iron–essential trace elements for thyroid hormone synthesis and metabolism
J Köhrle - International journal of molecular sciences, 2023 - mdpi.com
The adequate availability and metabolism of three essential trace elements, iodine,
selenium and iron, provide the basic requirements for the function and action of the thyroid …
selenium and iron, provide the basic requirements for the function and action of the thyroid …
[HTML][HTML] NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors
Z Zhong, C Zhang, S Ni, M Ma, X Zhang, W Sang, T Lv… - Redox biology, 2023 - Elsevier
Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …
Selenium atom-polarization effect determines TrxR-specific recognition of metallodrugs
M Chen, W Cao, J Wang, F Cai, L Zhu… - Journal of the …, 2022 - ACS Publications
Thioredoxin reductase (TrxR) is highly overexpressed in cancer cells to promote malignant
tumor survival. Designing drugs that inhibit TrxR activity is a promising approach to achieve …
tumor survival. Designing drugs that inhibit TrxR activity is a promising approach to achieve …
The thioredoxin system of mammalian cells and its modulators
AA Hasan, E Kalinina, V Tatarskiy, A Shtil - Biomedicines, 2022 - mdpi.com
Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
The role of the thioredoxin system in brain diseases
The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …
Natural dietary compounds in the treatment of arsenic toxicity
Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin
lesions and cancer being the most typical outcomes. Treating As-induced diseases …
lesions and cancer being the most typical outcomes. Treating As-induced diseases …
The role of selected trace elements in oxidoreductive homeostasis in patients with thyroid diseases
M Wróblewski, J Wróblewska, J Nuszkiewicz… - International journal of …, 2023 - mdpi.com
Impaired levels of selenium (Se), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn) and
iodine (I) in the organism may adversely affect the thyroid endocrine system. These trace …
iodine (I) in the organism may adversely affect the thyroid endocrine system. These trace …