Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Aging is a very complex process that is accompanied by a degenerative impairment in many
of the major functions of the human body over time. This inevitable process is influenced by …

The adequate availability and metabolism of three essential trace elements, iodine,
selenium and iron, provide the basic requirements for the function and action of the thyroid …

Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …

Thioredoxin reductase (TrxR) is highly overexpressed in cancer cells to promote malignant
tumor survival. Designing drugs that inhibit TrxR activity is a promising approach to achieve …

Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …

The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …

Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin
lesions and cancer being the most typical outcomes. Treating As-induced diseases …

Impaired levels of selenium (Se), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn) and
iodine (I) in the organism may adversely affect the thyroid endocrine system. These trace …