Nucleotide metabolism: a pan-cancer metabolic dependency

NJ Mullen, PK Singh - Nature Reviews Cancer, 2023 - nature.com
Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Mitochondria as playmakers of apoptosis, autophagy and senescence

M Abate, A Festa, M Falco, A Lombardi, A Luce… - Seminars in cell & …, 2020 - Elsevier
Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

R Singhal, YM Shah - Journal of Biological Chemistry, 2020 - ASBMB
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Large Stokes shift benzothiazolium cyanine dyes with improved intramolecular charge transfer (ICT) for cell imaging applications

CS Abeywickrama - Chemical Communications, 2022 - pubs.rsc.org
Intramolecular Charge Transfer (ICT) is a crucial photophysical phenomenon that can be
used to improve the Stokes' shift in fluorescent dyes. The introduction of molecular …

Mitochondria, bioenergetics and apoptosis in cancer

PJ Burke - Trends in cancer, 2017 - cell.com
Until recently, the dual roles of mitochondria in ATP production (bioenergetics) and
apoptosis (cell life/death decision) were thought to be separate. New evidence points to a …

Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition

Y Rai, R Pathak, N Kumari, DK Sah, S Pandey… - Scientific reports, 2018 - nature.com
Metabolic viability based high throughput assays like MTT and MTS are widely used in
assessing the cell viability. However, alteration in both mitochondrial content and …

The roles of reactive oxygen species and antioxidants in cryopreservation

JS Len, WSD Koh, SX Tan - Bioscience reports, 2019 - portlandpress.com
Cryopreservation has facilitated advancement of biological research by allowing the storage
of cells over prolonged periods of time. While cryopreservation at extremely low …

Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells

DP Bai, XF Zhang, GL Zhang, YF Huang… - International journal …, 2017 - Taylor & Francis
Background Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products
such as paint, surface coating, and cosmetics, and recently, they have been explored in …

A photostable AIE luminogen for specific mitochondrial imaging and tracking

CWT Leung, Y Hong, S Chen, E Zhao… - Journal of the …, 2013 - ACS Publications
Tracking the dynamics of mitochondrial morphology has attracted much research interest
because of its involvement in early stage apoptosis and degenerative conditions. To follow …