[HTML][HTML] Understanding the complex genetics and molecular mechanisms underlying glaucoma

W Wang, H Wang - Molecular Aspects of Medicine, 2023 - Elsevier
Glaucoma is the leading cause of irreversible blindness worldwide. Currently the only
effective treatment for glaucoma is to reduce the intraocular pressure, which can halt the …

Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and …

T Kang, Y Zhou, C Fan, Y Zhang, Y Yang, J Jiang - EPMA Journal, 2024 - Springer
Background Glaucoma is the leading cause of irreversible blindness worldwide. Normal
tension glaucoma (NTG) is a distinct subtype characterized by intraocular pressures (IOP) …

Denoising OCT videos based on temporal redundancy

E Richer, MM Solano, F Cheriet, MR Lesk… - Scientific Reports, 2024 - nature.com
The identification of eye diseases and their progression often relies on a clear visualization
of the anatomy and on different metrics extracted from Optical Coherence Tomography …

Biomechanical Strain Responses in the Optic Nerve Head Region in Glaucoma Patients After Intraocular Pressure Lowering

Z Yuan, CA Czerpak, MS Kashaf, HA Quigley… - medRxiv, 2023 - medrxiv.org
Objective To measure strain values and their association with intraocular pressure (IOP)
change across five posterior eye regions in glaucoma patients. Design Cohort study …

Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains

T Chuangsuwanich, ME Nongpiur, FA Braeu… - American Journal of …, 2025 - Elsevier
Purpose (1) To assess whether neural tissue structure and biomechanics could predict
functional loss in glaucoma;(2) To evaluate the importance of biomechanics in making such …

Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications

D Ma, LR Pasquale, MJA Girard, CKS Leung… - Frontiers in …, 2023 - frontiersin.org
Artificial intelligence (AI) has been approved for biomedical research in diverse areas from
bedside clinical studies to benchtop basic scientific research. For ophthalmic research, in …

Adduction induces large optic nerve head deformations in subjects with normal-tension glaucoma

T Chuangsuwanich, TA Tun, FA Braeu… - British Journal of …, 2024 - bjo.bmj.com
Purpose To assess intraocular pressure (IOP)-induced and gaze-induced optic nerve head
(ONH) strains in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma …

[HTML][HTML] A Noninvasive Clinical Method to Measure in Vivo Mechanical Strains of the Lamina Cribrosa by OCT

V Hannay, C Czerpak, HA Quigley, TD Nguyen - Ophthalmology Science, 2024 - Elsevier
Objective To measure mechanical strain of the lamina cribrosa (LC) after intraocular
pressure (IOP) change produced 1 week after a change in glaucoma medication. Design …

AI-based clinical assessment of optic nerve head robustness superseding biomechanical testing

FA Braeu, T Chuangsuwanich, TA Tun… - British Journal of …, 2024 - bjo.bmj.com
Background/aims To use artificial intelligence (AI) to:(1) exploit biomechanical knowledge of
the optic nerve head (ONH) from a relatively large population;(2) assess ONH robustness …

Lamina Cribrosa Morphology in Normal Tension Glaucoma According to the Location of Visual Field Defects

YS Kang, Z Haowei, MS Sung, SW Park - Journal of Glaucoma, 2023 - journals.lww.com
Purpose: The aim of this study was to investigate morphologic differences in the LC in
normal tension glaucoma (NTG) according to the location of VF defects. Design: This study …