Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Age-related complications such as neurodegenerative disorders are increasing and remain
cureless. The possibility of altering the progression or the development of these …

Hemolytic conditions in preterm neonates, including Rhesus (Rh) disease, can lead to
mortality and long-term impairments due to bilirubin neurotoxicity. Universal access to Rh …

UDP-glucuronosyltransferases (UGTs) form a multigenic family of membrane-bound
enzymes expressed in various tissues, including brain. They catalyze the formation of β-D …

Background Sepsis and jaundice are common conditions in newborns that can lead to brain
damage. Though lipopolysaccharide (LPS) is known to alter the integrity of the blood-brain …

Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with
neuroprotective properties. Our previous studies demonstrated their anti-apoptotic, anti …

Purpose Epidemiological and intervention studies have attempted to link the health effects of
a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in …

The onset of intracerebral hemorrhage and its progression toward acute brain injury have
been correlated with the concentration of unconjugated bilirubin (BR). In addition, BR has …

Bilirubin-induced neurological damage (BIND), which might progress to kernicterus, occurs
as a consequence of defects in the bilirubin conjugation machinery, thus enabling albumin …