The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

In neurodegenerative diseases, neurodegeneration has been related to several
mitochondrial dynamics imbalances such as excessive fragmentation of mitochondria …

Neurological disorders (NDs) are characterized by progressive neuronal dysfunction
leading to synaptic failure, cognitive impairment, and motor injury. Among these diseases …

Alzheimer's disease (AD) is characterized by cognitive impairment and the presence of
neurofibrillary tangles and senile plaques in the brain. Neurofibrillary tangles are composed …

Mitochondrial dysfunction is a significant factor in the development of Alzheimer's disease
(AD). Previous studies have demonstrated that the expression of tau cleaved at Asp421 by …

Neurons are permanent cells whose key feature is information transmission via chemical
and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain …

Mitochondria generate ATP essential for neuronal growth, function, and regeneration. Due
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …