Molecule representation learning (MRL) has been extensively studied and current methods
have shown promising power for various tasks, eg, molecular property prediction and target …

Abstract HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the
insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue …

Integrase (IN) is the newest validated target against AIDS and retroviral infections. The
remarkable activity of raltegravir (Isentress®) led to its rapid approval by the FDA in 2007 as …

A series of new and novel Schiff base derivatives were synthesized and investigated as
potential new inhibitors of Jack bean urease. The most potent compounds were 3f with (Ki …

A new series of quinoxaline-hydrazidehydrazone-1, 2, 3-triazole hybrids, 14a–j, 15a–j and
16a–e, was designed, synthesized and screened for in vitro α-glucosidase and antioxidant …

A series of benzylidene hydrazides (1–20) was synthesized and tested, in vitro, for
antibacterial, antifungal and antiviral activities. The microbial screening results indicated that …

A series of 2-hydroxy-1, 3-dioxoisoquinoline-4-carboxamides featuring an N-hydroxyimide
chelating functionality was evaluated for their inhibitory properties against human …

Several novel 1, 3-disubstituted β-carboline derivatives bearing a substituted
carbohydrazide group at C-3 were synthesized and evaluated for their antiviral activity …

A series of substituted hydrazide derivatives have been synthesized and screened for their
in vitro antimicrobial activities against five representative microorganisms. The results of …

Hydrazides and hydrazones are present in many of the bioactive heterocyclic compounds
that are of wide interest because of their diverse biological and clinical applications. This …