Simple Summary Genetic molecular testing is starting to become part of standard clinical
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …

Clinical care of osteosarcoma (OSA) in companion dogs has been relatively static during the
past 20 years. The disease of OSA can be described as one of “life and limb.” The limb pain …

A hallmark of osteosarcoma in both human and canine tumors is somatic fragmentation and
rearrangement of chromosome structure which leads to recurrent increases and decreases …

Background Osteosarcoma is the most common primary malignant tumour of bone occurring
in children and young adolescents and is characterised by complex genetic and epigenetic …

Osteosarcoma has a unique tumor microenvironment (TME), which is characterized as a
complex microenvironment comprising of bone cells, immune cells, stromal cells, and …

Osteosarcoma (OSA) is the most common bone tumor in both humans and dogs and has a
nearly ten-fold higher incidence in dogs than humans. Despite advances in the treatment of …

Background Canine and human osteosarcoma are similar in clinical presentation and tumor
genomics. Giant breed dogs experience elevated osteosarcoma incidence, and taller stature …

Background: Osteosarcoma (OS) is a primary malignant bone tumor arising from
mesenchymal cells. The standard clinical treatment for OS involves extensive tumor …

No. of pages in text:(463) 3% of cancer patients are classified as CUP (cancer of unknown
primary). For CUP patients, survival averages less than one year, and at five years, only …

Given the propensity of numerous malignancies to metastasize to the skeleton, the bone
microenvironment is arguably one of the most hospitable sites within the human body for …