Introduction: Cigarette smoke associated polycyclic aromatic hydrocarbons can induce key
drug-metabolizing enzymes of cytochrome P450 and isoforms of the glucuronyl transferases …

Cytochrome P-450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of a variety of
toxicants including nitrosamines, benzene, vinyl chloride, and halogenated solvents such as …

BACKGROUND AND PURPOSE Patients with diabetes mellitus require pharmacotherapy
with numerous medications. However, the effect of diabetes on drug biotransformation is not …

The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and
evolving field of research. CYPs are present and active in the brain, with heterogeneous …

Monkeys, especially macaques, including cynomolgus (Macaca fascicularis) and rhesus
monkeys (Macaca mulatta), are frequently used in drug metabolism studies due to their …

Purpose The currently held mechanistic understanding of microsomal cytochrome P450s
(CYPs) seeks that diverse drug molecules bind within the deep-seated distal heme pocket …

Characteristics of twelve cytochromes P450 (CYPs) from cynomolgus monkeys were
compared with those of human CYPs that play an important role in drug metabolism. Eleven …

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a
potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Smoking slows the metabolism of
nicotine and accelerates the metabolism of chlorzoxazone.• Nicotine is a useful probe for …

CYP2E1, an inducible enzyme present in different human tissues, metabolizes several
potentially toxic substances including many volatile organic compounds (VOCs). One …