[HTML][HTML] Hyaluronic acid: molecular mechanisms and therapeutic trajectory

RC Gupta, R Lall, A Srivastava, A Sinha - Frontiers in veterinary …, 2019 - frontiersin.org
Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent …

S Vasvani, P Kulkarni, D Rawtani - International journal of biological …, 2020 - Elsevier
Hyaluronic acid (HA) is a large non-sulphated glycosaminoglycan that is an important
component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in …

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

P Rousselle, F Braye, G Dayan - Advanced Drug Delivery Reviews, 2019 - Elsevier
Cutaneous wound healing in adult mammals is a complex multi-step process involving
overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation …

Evidence‐based (S3) Guideline on (anogenital) Lichen sclerosus

G Kirtschig, K Becker, A Günthert… - Journal of the …, 2015 - Wiley Online Library
Lichen sclerosus (LS) is an inflammatory skin disease that usually involves the anogenital
area. All patients with symptoms or signs suspicious of lichen sclerosus should be seen at …

Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment

A Fakhari, C Berkland - Acta biomaterialia, 2013 - Elsevier
Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of
applications in medicine, including scaffolding for tissue engineering, dermatological fillers …

Hyaluronan as an immune regulator in human diseases

D Jiang, J Liang, PW Noble - Physiological reviews, 2011 - journals.physiology.org
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

CD44: from adhesion molecules to signalling regulators

H Ponta, L Sherman, PA Herrlich - Nature reviews Molecular cell …, 2003 - nature.com
Cell-adhesion molecules, once believed to function primarily in tethering cells to
extracellular ligands, are now recognized as having broader functions in cellular signalling …

Hyaluronan in wound healing: rediscovering a major player

KL Aya, R Stern - Wound repair and regeneration, 2014 - Wiley Online Library
Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …

Hyaluronan: from extracellular glue to pericellular cue

BP Toole - Nature Reviews Cancer, 2004 - nature.com
Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

Hyaluronan: biosynthesis and signaling

D Vigetti, E Karousou, M Viola, S Deleonibus… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …