Structure-based drug design studies toward the discovery of novel chalcone derivatives as potential epidermal growth factor receptor (EGFR) inhibitors
Human Epidermal Growth Factor Receptor-1 (EGFR), a transmembrane tyrosine kinase
receptor (RTK), has been associated with several types of cancer, including breast, lung …
receptor (RTK), has been associated with several types of cancer, including breast, lung …
QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y 12) antagonist
P2Y12 has a key role in platelet aggregation and thrombus formation via an ADP-induced
platelet activation mechanism. Recently, P2Y12 antagonists have become of great interest …
platelet activation mechanism. Recently, P2Y12 antagonists have become of great interest …
[PDF][PDF] Synthesis, molecular docking and antioxidant evaluation of benzylidene ketone derivatives
BO Al-Najjar - Jordan J. Biol. Sci, 2018 - jjbs.hu.edu.jo
Four benzylidene ketone derivatives were synthesized by reacting 4-nitrobenzaldehyde with
several ketone derivatives. The synthesized compounds A, B, C and D had shown …
several ketone derivatives. The synthesized compounds A, B, C and D had shown …
[PDF][PDF] FOR THIAZOLIDINE-2, 4-DIONE DERIVATIVES AS INHIBITORY ACTIVITIES OF 15-PGDH USING MLR AND ANN
Quantitative structure activity relationship studies were applied on a series of 22 molecules
of thiazolidine-2, 4-dione. The compounds used are potent inhibitors of the 15 …
of thiazolidine-2, 4-dione. The compounds used are potent inhibitors of the 15 …
Investigation of 15-hydroxyprostaglandin dehydrogenase catalytic reaction mechanism by molecular dynamics simulations
BO Al-Najjar - Journal of Molecular Graphics and Modelling, 2018 - Elsevier
hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin metabolizing enzyme
that oxidizes the hydroxyl group at carbon 15 (C15). The aim of the present work is to …
that oxidizes the hydroxyl group at carbon 15 (C15). The aim of the present work is to …
Compositions and methods of modulating short-chain dehydrogenase
S Markowitz, Y Yuan, Y Zhang, J Ready… - US Patent 11,718,589, 2023 - Google Patents
US11718589B2 - Compositions and methods of modulating short-chain dehydrogenase -
Google Patents US11718589B2 - Compositions and methods of modulating short-chain …
Google Patents US11718589B2 - Compositions and methods of modulating short-chain …
Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11690847B2 - Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF
inhibitors and uses thereof - Google Patents US11690847B2 - Combinations of 15-PGDH …
inhibitors and uses thereof - Google Patents US11690847B2 - Combinations of 15-PGDH …