Immune mechanisms in type 1 diabetes
M Wållberg, A Cooke - Trends in immunology, 2013 - cell.com
There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …
Progress in immune-based therapies for type 1 diabetes
M Von Herrath, M Peakman… - Clinical & Experimental …, 2013 - academic.oup.com
Immune-based therapies that prevent type 1 diabetes or preserve metabolic function
remaining at diagnosis have become a major objective for funding agencies and …
remaining at diagnosis have become a major objective for funding agencies and …
Islet-derived CD4 T cells targeting proinsulin in human autoimmune diabetes
AW Michels, LG Landry, KA McDaniel, L Yu… - Diabetes, 2017 - Am Diabetes Assoc
Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …
as a pathway involved in the development of autoimmunity. However, the mechanisms that …
Autoreactive T cells specific for insulin B: 11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
J Yang, IT Chow, T Sosinowski… - Proceedings of the …, 2014 - National Acad Sciences
Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated
that a crucial insulin epitope (B: 9-23) is presented to diabetogenic CD4 T cells by IAg7 in a …
that a crucial insulin epitope (B: 9-23) is presented to diabetogenic CD4 T cells by IAg7 in a …
[HTML][HTML] Demonstration of tissue resident memory CD8 T cells in insulitic lesions in adult patients with recent-onset type 1 diabetes
Subtypes of CD8+ T cells in insulitic lesions in biopsy specimens from six subjects with
recent-onset type 1 diabetes (T1D) and six nondiabetic matched controls were analyzed …
recent-onset type 1 diabetes (T1D) and six nondiabetic matched controls were analyzed …
Protecting stem cell derived pancreatic beta-like cells from diabetogenic T cell recognition
R Castro-Gutierrez, A Alkanani, CE Mathews… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes results from an autoimmune attack directed at pancreatic beta cells
predominantly mediated by T cells. Transplantation of stem cell derived beta-like cells (sBC) …
predominantly mediated by T cells. Transplantation of stem cell derived beta-like cells (sBC) …
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
HA Abdelsamed, CC Zebley, H Nguyen… - Nature …, 2020 - nature.com
The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive
potential despite having access to a constant source of antigen. To investigate the long-lived …
potential despite having access to a constant source of antigen. To investigate the long-lived …
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
L Yeo, A Woodwyk, S Sood, A Lorenc… - The Journal of …, 2018 - Am Soc Clin Investig
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice
ME Azoury, M Tarayrah, G Afonso, A Pais, ML Colli… - Diabetes, 2020 - Am Diabetes Assoc
The antigenic peptides processed by β-cells and presented through surface HLA class I
molecules are poorly characterized. Each HLA variant (eg, the most common being HLA-A2 …
molecules are poorly characterized. Each HLA variant (eg, the most common being HLA-A2 …