There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …

Immune-based therapies that prevent type 1 diabetes or preserve metabolic function
remaining at diagnosis have become a major objective for funding agencies and …

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated
that a crucial insulin epitope (B: 9-23) is presented to diabetogenic CD4 T cells by IAg7 in a …

Subtypes of CD8+ T cells in insulitic lesions in biopsy specimens from six subjects with
recent-onset type 1 diabetes (T1D) and six nondiabetic matched controls were analyzed …

Type 1 diabetes results from an autoimmune attack directed at pancreatic beta cells
predominantly mediated by T cells. Transplantation of stem cell derived beta-like cells (sBC) …

The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive
potential despite having access to a constant source of antigen. To investigate the long-lived …

In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …

The antigenic peptides processed by β-cells and presented through surface HLA class I
molecules are poorly characterized. Each HLA variant (eg, the most common being HLA-A2 …