Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes
responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have∼ 40 E2s …

Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a
potential pharmacological target in cancer. Abnormal expression of IAPs can lead to …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Misregulated innate immune signaling and cell death form the basis of much human disease
pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently …

Several of the inhibitor of apoptosis protein (IAP) family members regulate apoptosis in
response to various cellular assaults. Some members are also involved in cell signalling …

The family of ubiquitin‐conjugating (E2) enzymes is characterized by the presence of a
highly conserved ubiquitin‐conjugating (UBC) domain. These domains accommodate the …

The Arabidopsis thaliana pho2 mutant, which is defective in a ubiquitin-conjugating E2
enzyme, displays inorganic phosphate (Pi) toxicity as a result of enhanced uptake and root …

The caspases are unique proteases that mediate the major morphological changes of
apoptosis and various other cellular remodeling processes. As we catalog and study the …

The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat
motifs, through which they interact with various other proteins. Many IAPs also have another …

cIAPs (cellular inhibitor of apoptosis proteins) 1 and 2 are able to regulate apoptosis when
ectopically expressed in recipient cells and probably also in vivo. Previous work suggested …