Globally, greater than 30 million individuals are afflicted with disorders of the nervous
system accompanied by tens of thousands of new cases annually with limited, if any …

The inflammasome serves as a mechanism by which the body senses damage or danger.
These multiprotein complexes form in the cytosol of myeloid, epithelial and potentially other …

The development of the central nervous system is subject to a broad range of disruptions
both environmental and genetic in nature. These disruptions to neurodevelopmental …

Inflammasome, a cytosolic multi-protein complex, assembly is a response to sensing
intracellular pathogenic and endogenic danger signals followed by caspase-1 activation …

Background: Hypoxia-ischemia (HI) results in increased activation of Ca 2+/calmodulin
kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates …

Background Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal morbidity
and mortality worldwide. While the application of therapeutic hypothermia has improved …

Caspase-2 has features of both initiator and effector caspases. Previously, we have shown
that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a …

The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are
involved in a variety of cellular functions including the regulation of inflammation and …

Background. Protein tyrosine phosphatases (PTPs) in conjunction with protein tyrosine
kinases (PTKs) regulate cellular processes by posttranslational modifications of signal …

Protein tyrosine kinase (PTK) mediated the tyrosine phosphorylation modification of
neuronal receptors and ion channels. Whether such modification resulted in changes of …