Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11

D Jiang, X Wu, X Sun, W Tan, X Dai, Y Xie, A Du… - Journal of …, 2022 - Springer
Background Acute myeloid leukemia (AML) is a malignant clonal disease of hematopoietic
stem-and progenitor-cell origin. AML features massive proliferation of abnormal blasts and …

The bone mesenchymal stem cell-derived exosomal miR-146a-5p promotes diabetic wound healing in mice via macrophage M1/M2 polarization

X Zhou, C Ye, L Jiang, X Zhu, F Zhou, M Xia… - Molecular and Cellular …, 2024 - Elsevier
A diabetic wound is a refractory disease that afflicts patients globally. MicroRNA-146a-5p
(miR-146a-5p) is reported to represent a potential therapeutic target for diabetic wounds …

Advances of mesenchymal stem cells and their derived extracellular vesicles as a promising therapy for acute respiratory distress syndrome: from bench to clinic

X Zhuang, Y Jiang, X Yang, L Fu, L Luo… - Frontiers in …, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung injury
characterized by diffuse alveolar damage. The period prevalence of ARDS was 10.4% of …

Mesenchymal stem cells as a gene delivery tool: Promise, problems, and prospects

N Attia, M Mashal, G Puras, JL Pedraz - Pharmaceutics, 2021 - mdpi.com
The cell-based approach in gene therapy arises as a promising strategy to provide safe,
targeted, and efficient gene delivery. Owing to their unique features, as homing and tumor …

Cell-based therapy for the treatment of glioblastoma: an update from preclinical to clinical studies

N Attia, M Mashal, S Pemminati, A Omole… - Cells, 2021 - mdpi.com
Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents
about 60% of all adult primary brain tumors. It is notorious for its extremely low (~ 5%) 5-year …

Cholesterol-linoleic acid liposomes induced extracellular vesicles secretion from immortalized adipose-derived mesenchymal stem cells for in vitro cell migration

JW Chen, FF Liew, HW Tan, M Misran… - Artificial Cells …, 2023 - Taylor & Francis
Extracellular vesicles (EVs) are small vesicles that are naturally released by cells and play a
crucial role in cell-to-cell communication, tissue repair and regeneration. As naturally …

Mesenchymal stromal cell-derived extracellular vesicles as biological carriers for drug delivery in cancer therapy

MC Sanmartin, FR Borzone, MB Giorello… - … in Bioengineering and …, 2022 - frontiersin.org
Cancer is the second leading cause of death worldwide, with 10.0 million cancer deaths in
2020. Despite advances in targeted therapies, some pharmacological drawbacks …

Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers

M Mashal, N Attia, S Grijalvo, R Eritja, G Puras… - Drug …, 2023 - Taylor & Francis
This study aims to explore the stability of lipo-polymeric niosomes/niosome-based pCMS-
EGFP complexes under different storage temperatures (25° C, 4° C, and− 20° C). To date …