Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and 

Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for 

This study aims to explain the challenges of teachers in the digital era 4.0 and readiness to
face these challenges. Through literature review. The author explains that there are several 

Treatmentresistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility 

Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to 

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the 

Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of 

Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant 

Key Clinical Points Depression in the Primary Care Setting Screening for depression and
suicidal thinking and behavior is important in the primary care setting. Distinguishing 

Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and
at six weeks, overall and according to diagnostic group. Design Prospective, double blind