Elucidating the details of the formation, stability, interactions, and reactivity of biomolecular
systems under extreme environmental conditions, including high salt concentrations in …

Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …

The extent of the effect of cellular crowding and cosolutes on the functioning of proteins and
cells is manifold and includes the stabilization of the biomolecular systems, the excluded …

Sampling and genomic efforts over the past decade have revealed an enormous quantity
and diversity of life in Earth's extreme environments. This new knowledge of life on Earth …

Osmolytes are essential for cellular function under ubiquitous osmotic stress.
Trimethylamine N-oxide (TMAO) is one such osmolyte that has gained remarkable attention …

High hydrostatic pressure affects the structure, dynamics, and stability of biomolecular
systems and is a key parameter in the context of the exploration of the origin and the …

Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the
substantia nigra pars compacta region of the brain and accumulation of aggregated forms of …

Biomolecular condensates can be functional (eg, as membrane-less organelles) or
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …

Clinical studies have identified Type 2 diabetes (T2D) as a risk factor of Alzheimer's disease
(AD). One of the potential mechanisms that link T2D and AD is the loss of cells associated …

Because organisms living in the deep sea and in the sub-seafloor must be able to cope with
hydrostatic pressures up to 1000 bar and more, their biomolecular processes, including …