Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …

Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths,
and the use of bioactive compounds has emerged as a novel and safe approach to solve …

An important determinant for oral squamous cell carcinoma (OSCC) onset and outcome is
the composition of the tumor microenvironment (TME). Thus, the study of the interactions …

The skin is the outermost layer and largest organ in the human body. Since the skin
interfaces with the environment, it has a variety of roles, including providing a protective …

Caveolin-1 (Cav-1), a structural and functional component in the caveolae, plays a critical
role in transcytosis, endocytosis, and signal transduction. Cav-1 has been implicated in the …

Phototherapy (PT) against melanoma continues to face significant great challenges with
suitable photosensitizers, a hypoxic tumor microenvironment (TME), and aberrant tumor …

Abstract Caveolin‐1 (CAV1), the main structural component of caveolae, is phosphorylated
at tyrosine‐14 (pCAV1), regulates signal transduction, mechanotransduction, and …

Despite recent progressions in cancer genomic and immunotherapies, advanced melanoma
still represents a life threat, pushing to optimise new targeted nanotechnology approaches …

Metastasis is the leading cause of cancer-related deaths, making the development of novel,
more effective therapies imperative to alleviate patient suffering. Metabolic switching is a …

Glycolytic and respiratory fluxes were analyzed in cancer and non-cancer cells. The steady-
state fluxes in energy metabolism were used to estimate the contributions of aerobic …