[HTML][HTML] GLP-1 physiology informs the pharmacotherapy of obesity

DJ Drucker - Molecular metabolism, 2022 - Elsevier
Background Glucagon-like peptide-1 receptor agonists (GLP1RA) augment glucose-
dependent insulin release and reduce glucagon secretion and gastric emptying, enabling …

The GDF15-GFRAL pathway in health and metabolic disease: friend or foe?

SN Breit, DA Brown, VWW Tsai - Annual review of physiology, 2021 - annualreviews.org
GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …

Obesity and the kidney: mechanistic links and therapeutic advances

K Yau, R Kuah, DZI Cherney, TKT Lam - Nature Reviews Endocrinology, 2024 - nature.com
Obesity is strongly associated with the development of diabetes mellitus and chronic kidney
disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also …

GLP-1 and IL-6 regulates obesity in the gut and brain

K Yang, Y Wu, Y He, J Dai, Y Luo, J Xie, W Ding - Life Sciences, 2024 - Elsevier
Obesity is a chronic metabolic disease characterized by excessive nutrient intake leading to
increased subcutaneous or visceral fat, resulting in pathological and physiological changes …

Physical exercise promotes memory function in diabetes mellitus rats: a look at glucagon like peptide-1 and glucagon like peptide-1 receptor

T Andraini, J Mardatillah… - Comparative …, 2023 - wageningenacademic.com
Diabetes mellitus (DM) is a metabolic disorder associated with declining of memory function.
Glucagon like peptide-1 (GLP-1) has a role on memory function; binding of GLP-1 and GLP …