NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

ABSTRACT STING (stimulator of interferon genes) is known to control the induction of innate
immune genes in response to the recognition of cytosolic DNA species, including the …

Inflammation is a healthy response to infection or danger and should be rapid, specific and
terminated once the threat has passed. Inflammatory diseases, where this regulation fails …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

The cellular innate immune system is essential for recognizing pathogen infection and for
establishing effective host defence. But critical molecular determinants responsible for …

Microorganisms that invade a vertebrate host are initially recognized by the innate immune
system through germline-encoded pattern-recognition receptors (PRRs). Several classes of …

The mammalian innate immune system detects the presence of microbial infection through
germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid …

Viral infection triggers host innate immune responses through activation of the transcription
factors NF-κB and IRF3, which coordinately regulate the expression of type-I interferons …