Nine major HLA class I supertypes account for the vast preponderance of HLA-A and-B polymorphism
Herein, we review the epitope approach to vaccine development, and discuss how
knowledge of HLA supertypes might be used as a tool in the development of such vaccines …
knowledge of HLA supertypes might be used as a tool in the development of such vaccines …
HLA supertypes and supermotifs: a functional perspective on HLA polymorphism
A large fraction of HLA class I, and possibly class II, molecules can be classified into
relatively few supertypes, characterized by overlapping peptide-binding repertoires and …
relatively few supertypes, characterized by overlapping peptide-binding repertoires and …
HLA class I supertypes: a revised and updated classification
Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …
T cells, short peptides derived from intracellular processing of proteins. The peptide …
Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice
V Dasari, LK McNeil, K Beckett, M Solomon… - Nature …, 2023 - nature.com
The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …
sclerosis has generated considerable interest in the development of an effective vaccine …
Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1
C Münz, KL Bickham, M Subklewe, ML Tsang… - The Journal of …, 2000 - rupress.org
The Epstein-Barr virus (EBV)-encoded nuclear antigen EBNA1 is critical for the persistence
of the viral episome in replicating EBV-transformed human B cells. Therefore, all EBV …
of the viral episome in replicating EBV-transformed human B cells. Therefore, all EBV …
Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.
Many people who remain persistently seronegative despite frequent HIV exposure have HIV-
specific immune responses. The study of these may provide information about mechanisms …
specific immune responses. The study of these may provide information about mechanisms …
Activation and adoptive transfer of Epstein–Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease
The treatment of Epstein–Barr virus (EBV)-associated lymphoproliferative disease (PTLD) in
EBV seronegative solid organ transplant recipients who acquire their EBV infection after …
EBV seronegative solid organ transplant recipients who acquire their EBV infection after …
Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
A Hildesheim, RJ Apple, CJ Chen… - Journal of the …, 2002 - academic.oup.com
Abstract Background: Nasopharyngeal carcinoma (NPC), which occurs at a
disproportionately high rate among Chinese individuals, is associated with Epstein-Barr …
disproportionately high rate among Chinese individuals, is associated with Epstein-Barr …
Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses
ANN Leen, P Meij, I Redchenko, J Middeldorp… - Journal of …, 2001 - Am Soc Microbiol
ABSTRACT Human CD4+ T-helper 1 cell responses to Epstein-Barr virus (EBV) infection
are likely to be important in the maintenance of virus-specific CD8+ memory and/or as …
are likely to be important in the maintenance of virus-specific CD8+ memory and/or as …
Direct immunosuppressive effects of EBV-encoded latent membrane protein 1
DF Dukers, P Meij, MBHJ Vervoort, W Vos… - The Journal of …, 2000 - journals.aai.org
In neoplastic cells of EBV-positive lymphoid malignancies latent membrane protein (LMP1)
is expressed. Because no adequate cellular immune response can be detected against …
is expressed. Because no adequate cellular immune response can be detected against …