The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in
scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for …

Recent studies have underscored questions about the balance of risk and benefit of RBC
transfusion. A better understanding of the nature and timing of molecular and functional …

Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo
generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate …

Nitric oxide participates in cellular signal transduction largely through S-nitrosylation of
allosteric and active-site cysteine thiols within proteins, forming S-nitroso-proteins (SNO …

Local vasodilation in response to hypoxia is a fundamental physiologic response ensuring
oxygen delivery to tissues under metabolic stress. Recent studies identify a role for the red …

Mammalian tissues produce nitric oxide (NO) to modify proteins at heme and sulfhydryl sites,
thereby regulating vital cell functions. The majority of NO produced is widely assumed to be …

▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O2)
gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) …

Abstract Inorganic nitrite (NO2−) is emerging as a regulator of physiological functions and
tissue responses to ischemia, whereas the more stable nitrate anion (NO3−) is generally …