An overview of sphingolipid metabolism: from synthesis to breakdown
S phingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …
Sphingosine-1-phosphate: an enigmatic signalling lipid
S Spiegel, S Milstien - Nature reviews Molecular cell biology, 2003 - nature.com
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …
Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity
C Cazalet, C Rusniok, H Brüggemann, N Zidane… - Nature …, 2004 - nature.com
Legionella pneumophila, the causative agent of Legionnaires' disease, replicates as an
intracellular parasite of amoebae and persists in the environment as a free-living microbe …
intracellular parasite of amoebae and persists in the environment as a free-living microbe …
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
M Maceyka, SG Payne, S Milstien, S Spiegel - Biochimica et Biophysica …, 2002 - Elsevier
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-
phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and …
phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and …
[HTML][HTML] Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide
(Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological …
(Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological …
Sphingosine 1-phosphate, a key cell signaling molecule
S Spiegel, S Milstien - Journal of Biological Chemistry, 2002 - ASBMB
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), 1 formed by
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
ML Allende, T Sasaki, H Kawai, A Olivera, Y Mi… - Journal of Biological …, 2004 - ASBMB
Sphingosine-1-phosphate (S1P), a lipid signaling molecule that regulates many cellular
functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase …
functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase …
Lysophospholipids--receptor revelations
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid
(LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill …
(LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill …
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death
JR Van Brocklyn, JB Williams - … and Physiology Part B: Biochemistry and …, 2012 - Elsevier
Sphingolipids are components of all eukaryotic cells that play important roles in a wide
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …