Chromatin is a highly dynamic structure whose plasticity is achieved through multiple
processes including the posttranslational modification of histone tails. Histone modifications …

p21cip1/waf1 is a central regulator of cell cycle control and survival. While mutations are
rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms …

Pathogenic variants in KMT5B, a lysine methyltransferase, are associated with global
developmental delay, macrocephaly, autism, and congenital anomalies (OMIM# 617788) …

The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates
is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that …

Lysine methyl transferase 5B (KMT5B) has been recently highlighted as a risk gene in
genetic studies of neurodevelopmental disorders (NDDs), specifically, autism spectrum …

Hepatocellular carcinoma (HCC) has a high rate of recurrence and poor prognosis, even
after curative surgery. Multikinase inhibitors have been applied for HCC patients, but their …

The post-translational modification of histone tails is a dynamic process that provides
chromatin with high plasticity. Histone modifications occur through the recruitment of …

Wings are an important flight organ of insects. Wing development is a complex process
controlled by a series of genes. The flightless wing pad transforms into a mature wing with …

Experimental manipulation of localization of the methyltransferase Suv420 at centromeres
suggests that proper localization of Suv420, or its placed epigenetic marks, are critical for …

Variation in KMT5B is considered a neurodevelopmental disorder risk and correlated to
anautism diagnosis in patients. Patient symptoms include hallmark autism phenotypes along …